Butch Hartman was inspired by popular cartoons and comic books while coming up with the idea for "Danny Phantom." During a 2006 interview with Danny Phantom Online Forums, he said, "When I was a kid, I used to love the show 'Jonny Quest' ... I thought, 'Man, I need a name for a character that was at least as cool as Jonny Quest.'" He started brainstorming last names, considering words like "Lightning" or "Power" before deciding on "Phantom."

After figuring out the main character's name, he knew the show would have something to do with hunting down ghosts or monsters. He thought about having Danny and his friends use gadgets to catch ghosts and solve mysteries. He was going to call the show "Danny Phantom and the Specter Detectors," but that idea was too similar to "Scooby-Doo," so he scrapped it and gained inspiration from comic books to create a new idea.

Hartman said in a YouTube video, "I really wanted to make Danny Phantom kind of a comic book character because I love superheroes ... so I decided to give Danny ghost powers."

Besides having superpowers, many comic book characters also have secret identities — Danny was given one of these as well, and of course, he needed an iconic jumpsuit to go along with his superhero alter ego.

Comic books also influenced many aspects of the show beyond the initial concept. Still images were often used during battles which also featured visual sound effects (like "Wham!" or "Pow!"), and nearly every episode had a title card that hinted at what would happen later on, similar to the cover of a comic book.