Premiering in 2007, "Resident Evil: Extinction" is where the films take a massive turn away from the games. In the "Resident Evil" games, most of the outbreaks are contained relatively well. Yes, cities can be overrun, and the virus can spread, but it's never really been on a global scale. There are organizations set in place, like the BSAA, that exist specifically to combat these situations, and so far, an outbreak has failed to expand on a global scale. Often contained to a single location, like the Spencer Mansion from the first game or the Baker Family's home in RE7, the games take a different approach to the threats of these viruses.
"Resident Evil: Extinction" explores the reality of the T-virus spreading on a global scale. This film primarily focuses on Alice's attempts to get herself and other survivors to Alaska, where they hope they might be safe from the worldwide outbreak. It also introduces a plot line of Umbrella attempting to clone Alice to replicate her abilities.
Although this film has taken a very different approach to spreading the T-virus than the games ever did, it introduced a few more iconic game characters, like the beloved villain, Albert Wesker (Jason O'Mara). Claire Redfield (Ali Larter), the sister of Chris Redfield, also makes her debut here.