Kingpin's ability to live through even the most precarious situations ties back to his comic book adventures, where death has long surrounded him. He lost his wife Vanessa, his son Richard, and many associates during his attempts to maintain his empire.
There is some basis for Vincent D'Onofrio naming Spider-Man and Daredevil as two heroes who could take down Kingpin for good, even if neither actually kills him. In "Daredevil" #50 (by Brian Michael Bendis, Alex Maleev, Matt Hollingsworth, and Cory Petit), the titular hero fights back against Kingpin. Daredevil embarrasses him in a fight where he bloodies the villain, knocking him to the ground and declaring New York is his. Meanwhile, in "The Amazing Spider-Man" #542 (by J. Michael Straczynski, Ron Garney, Bill Reinhold, Matt Milla, and Cory Petit), Peter Parker, driven by anger over an assassination attempt by Kingpin that left Aunt May in a coma, visits him in jail, nearly beating the mobster to death and telling him he'll finish the job if May succumbs to her injuries.
Considering both Spider-Man and Daredevil have long instilled no-kill rules, Kingpin has survived his deadliest encounters with the heroes. And if he has the same survivability in the Marvel Cinematic Universe as in the comics, Donofrio's Kingpin will likely remain a prominent figure for the foreseeable future.
