Despite not gaining a ton of viewership traction, the consensus among critics is overwhelmingly positive — Wayne even has a 100% critics score on Rotten Tomatoes. Nerdist's reviewer summed it up well: "The writers of Deadpool produced one of the best TV shows of the decade and you've probably never seen it." Much of the praise goes to Simmons for the writing — specifically, the interweaving of different genres and tones, as well as the overarching themes presented. IndieWire's reviewer called it "thoughtful, engrossing and altogether joyful," while Decider said, "Wayne is hilarious and heartfelt, and has a golden opportunity to say something meaningful about abuse, poverty and love."

Further, the LA Times brought attention to the way that Wayne pushes boundaries to the point that it may not connect with every viewer, but is clearly not holding back. "Tender and violent, profane and thoughtful, simple and complicated, obvious and subtle, sweet and upsetting, an intermittently bloody hymn to goodness and innocence, and delicately acted even as it runs to extremes," the review reads in part. With captivating characters and a strong plot, it seems as though Wayne is a perfect dark comedy show to check out next.