Like Bill and Frank, Henry and Sam are two supporting characters from "The Last of Us" game that Joel and Ellie meet for a brief time while escaping from the hostile city of Pittsburgh. In the game, Henry and Sam are brothers, and like Joel and Ellie, they were traveling through the city when they are ambushed by the local militant faction. After escaping, they went into hiding in the city, while Henry devised a plan to escape, which he was only able to do with Joel's assistance. Sam, Henry's younger brother, is about Ellie's age, and the two bond before he is bitten and becomes infected.
In the show, Henry are Sam were residents of Kansas City during FEDRA's rule. To afford medicine for Sam, Henry sold secrets about the revolutionary faction which resulted in the death of Kathleen's brother. Once Kathleen's group overthrows FEDRA, she mercilessly sets out to capture and kill Henry, trying to avenge the death of her brother. With the help of a local doctor, Henry and Sam are able to hide until Joel and Ellie arrive, giving them the opportunity to escape.
In the show, Sam is younger than his game counterpart, and is also deaf, using a magic slate paper saver to communicate with Ellie. Sadly, he and his brother meet the same tragic fates as they did in the game after Sam is bitten and Henry takes his own life, unable to cope with losing his brother.