The same year his character was killed on Game of Thrones, Brodie-Sangster booked the role of Newt in The Maze Runner, a film adaptation of the dystopian young adult book series by James Dashner. The story follows 16-year-old Thomas (Dylan O'Brien), a boy who wakes up with no memory except his name, on an empty plain completely surrounded by a massive maze. He must work with a bunch of other kids to figure out how to escape the strange environment. Brodie-Sangster's Newt is one of the boys that initially welcomes Thomas to what they call the Glade. He is the second-in-command of their unique society, a quiet-yet-wise young man who quickly establishes a close friendship with Thomas.
There were plans in place from the outset to adapt the whole trilogy. The second film, The Scorch Trials, released in 2015, with the third film The Death Cure expected close behind. Production was forced to stop when there was a dangerous accident on set involving O'Brien, who spent a lot of time recovering from the physical and mental trauma of what happened. Thankfully, he eventually felt comfortable enough to get back to filming, and the final film, The Death Cure, finally came out in 2018.