In 2009, Dushku reunited with Joss Whedon for this science fiction series he created specifically for his Buffy-era muse. "I called Joss, who was actually the only person on my mind and we went to lunch where I asked him to write me the coolest show that he has ever written and he accepted," Dushku told The TV Addict at the time. Dushku was a producer on the show.

Dushku played Echo, a woman who supposedly voluntarily signed a contract to wipe her memory for five years and become a blank-slate special operator that could be programmed with temporary memories and personalities and rented by people who would use her for criminal or other unsavory purposes. The corporation that provided this service operated out of safe houses called "Dollhouses." Echo, however, could remember parts of who she really was, which was a problem for everyone.

By Whedon's own admission, the ambitious series never fully put all of its ideas together in a coherent way, and it failed to secure an audience (via Syfy Wire). It was canceled after two seasons.