As you might expect, the success train didn't stop for Colleen O'Shaughnessey just because the decade changed. From the very beginning of the 2010s, she was accumulating credits left and right. She started off strong with an unspecified role in "Toy Story 3" before moving on. She continued to lend her voice to franchises like "Naruto," "Bleach," and "Digimon," but at the same time, she became a part of several new series. The most important of these might be "The Avengers: Earth's Mightiest Heroes" cartoon, where she portrayed the Wasp, a character who she named among her favorites (per her Michael Edwards interview).

In 2014 she began voicing another one of her most favorite characters, Tails, replacing Kate Higgins as the voice of the sidekick in the video game "Sonic Boom: Shattered Crystal," along with its sequels and the spinoff cartoon, "Sonic Boom." Though, this would not be her first appearance in the Sonic franchise, as three years prior she appeared as Charmy Bee in "Sonic Generations."